What does PSGL-1 do?

What does PSGL-1 do?

Function. PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels.

What cells express PSGL-1?

Although PSGL-1 is expressed on all T cell subsets, including both Th1 and Th2 CD4+ T cells, Th2 cells do not express the functional form and thus have decreased binding capacity to P- and E-selectins when compared to Th1 cells (46).

What does P selectin do?

Background—P-selectin mediates rolling of platelets and leukocytes on activated endothelial cells. After platelet activation, P-selectin is translocated from intracellular granules to the external membrane, whereas fibrinogen aggregates platelets by bridging glycoprotein (GP) IIb/IIIa between adjacent platelets.

What is Psgl in banking?

PSGL. Payroll System-General Ledger.

Is P-selectin and integrin?

P-selectin and PSGL-1 constitute the main receptor–ligand pair that mediates physical interactions between platelets and leukocytes. Activation of the leukocyte β1 and β2 integrins involves functional upregulation and activation-dependent conformational changes necessary for the integrins to recognize their ligands.

Is P-selectin a cytokine?

The P-selectin-dependent cytokine secretion shown in this study may be involved in the process of leukocyte transmigration.

What is PeopleSoft general ledger?

General Ledger serves as the core of the PeopleSoft Financial Management System. The PeopleSoft subsystem applications, such as Payables and Receivables, create accounting entries that you select to process in the journal generator. Run Journal Generator to create journals from these accounting tables.

Is E-selectin a protein?

All three selectins are type I transmembrane proteins with an N-terminal C-type lectin domain followed by an EGF repeat and a variable number of complement control protein (CCP) domains. The human E-selectin, L-selectin and P-selectin have six, two and nine CCP domains, respectively.